Membrane mechanics as a probe of ion-channel gating mechanisms

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Membrane mechanics as a probe of ion-channel gating mechanisms.

The details of conformational changes undergone by transmembrane ion channels in response to stimuli, such as electric fields and membrane tension, remain controversial. We approach this problem by considering how the conformational changes impose deformations in the lipid bilayer. We focus on the role of bilayer deformations in the context of voltage-gated channels because we hypothesize that ...

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ژورنال

عنوان ژورنال: Physical Review E

سال: 2008

ISSN: 1539-3755,1550-2376

DOI: 10.1103/physreve.78.041901